Screening for Chemosensitizers from Natural Plant Extracts through the Inhibition Mechanism of P-glycoprotein
نویسندگان
چکیده
منابع مشابه
Screening for Chemosensitizers from Natural Plant Extracts through the Inhibition Mechanism of P-glycoprotein
− P-gp plays a critical role in drug disposition and represents a mechanism for the development of multidrug resistance. Flavonoids, a major class of natural compounds widely present in foods and herbal products, have been shown to inhibit P-gp. Therefore, the aim of this study was to identify new candidate chemosensitizers by screening various plant extracts. The ability of natural plant extra...
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Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In this review, we discuss MDR in relation to P-glycoprotein (P-gp) and its down-regulation by natural bioactive molecules. P-gp, a unique ATP-dependent...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Investigation
سال: 2010
ISSN: 2093-5552
DOI: 10.4333/kps.2010.40.5.269